Root analogue implant creation: Establishing procedures for the general dentist

The possibility of replacing damaged teeth with custom-made root analogue implants was initially suggested around 1969 and reintroduced by Lungren et al. in 1992. The latter authors created custom implants in titanium and reported good osteointegration and aesthetic results. Following this effort there has been an increasing focus on custom root analogue implants as a replacement for ‘screw-type’ implants. Given the availability of software to manipulate 3D image data and the rapid rise of 3D printing technology, the question arises as to whether a general dentist can produce their own implants. Here we test the feasibility of practitioners producing custom root analogue implants, detail some of the problems encountered, and provide suggestions to support implant creation by general dentists

GenX Inhibits P-glycoprotein and Breast Cancer Resistance Protein Transport Activity and Expression at the Blood-Brain Barrier in Sprague-Dawley Rats

GenX (CAS No. 62037-80-3) is a replacement for perfluorooctanoic acid (PFOA) as a chemical precursor in fluoropolymer manufacturing. The compound is a persistent contaminant in drinking water and air. To address the potential for CNS toxicity, we investigated the effects of low concentrations (0.01 – 1000 nM) of GenX on ATP-Binding Cassette transporter activity and expression at the blood-brain barrier. Using an ex vivo steady-state luminal fluorescence-based assay, we found that 1 - 1000 nM GenX rapidly inhibited P-glycoprotein (P-gp, ABCB1) and Breast Cancer Resistance Protein (BCRP, ABCG2) activity in SD rats and in human ovarian cancer cells. Inhibition of efflux transport reduces the neuroprotective function of the BBB, potentially exposing the CNS to toxic substrates. If GenX has a similar effect in other P-gp- and BCRP-expressing tissues, then changes in pharmacokinetics of xenobiotics could occur.Master of Scienc

A POF model for short fiber segments in avionics applications

Plastic Optical Fibres (POF) have now been a well-established media for transporting high-speed at low cost in short distance communications systems, and avionics is the latest segment where these fibers are becoming an important factor. In fact, the POF''s flexibility and ease of installation make this fiber a great option for the replacement by fiber of some of the existing aircraft data links. We propose a new model for short fiber links that are suitable for plane''s systems that involve a lot of connectors; the model is built around two important properties, namely, power transfer among modes and attenuation. The model expands on our previous work on the subject and is based on detailed experimental measurements for various fiber types and lengths

Transmission performance of plastic optical fibers designed for avionics platforms

Plastic optical fibers (POFs) have been proposed and implemented in the avionics environment lately, and temperature is naturally a big factor that can affect their performance in those platforms. We present an experimental characterization of the transmission properties of POFs comparing the performance of standard fibers with that of fibers designed to sustain high temperatures, such as those on avionics platforms. We tested different step-index 1-mm poly(methyl methacrylate) single-core and multicore fibers. Frequency response, bit error rate (BER), attenuation, and output power distribution were measured for each fiber type at room temperature. In addition, BER and fiber attenuation were monitored as a function of temperature, intentionally exceeding the temperature limits to obtain the true temperature ranges and to assess the performance penalty. The same properties were obtained for the overheated fibers and compared to those for nonheated fibers of the same type to reveal permanent performance degradation

Overcoming challenges in large-core SI-POF-based system-level modeling and simulation

The application areas for plastic optical fibers such as in-building or aircraft networks usually have tight power budgets and require multiple passive components. In addition, advanced modulation formats are being considered for transmission over plastic optical fibers (POFs) to increase spectral efficiency. In this scenario, there is a clear need for a flexible and dynamic system-level simulation framework for POFs that includes models of light propagation in POFs and the components that are needed to evaluate the entire system performance. Until recently, commercial simulation software either was designed specifically for single-mode glass fibers or modeled individual guided modes in multimode fibers with considerable detail, which is not adequate for large-core POFs where there are millions of propagation modes, strong mode coupling and high variability. These are some of the many challenges involved in the modeling and simulation of POF-based systems. Here, we describe how we are addressing these challenges with models based on an intensity-vs-angle representation of the multimode signal rather than one that attempts to model all the modes in the fiber. Furthermore, we present model approaches for the individual components that comprise the POF-based system and how the models have been incorporated into system-level simulations, including the commercial software packages SimulinkTM and ModeSYSTM

Voces y experiencias de mujeres mapuche en tiempos de revoluciones feministas

Ens hem proposat en aquest article, des d'una aposta descolonial i amb perspectiva interseccional, analitzar les lluites històriques que dones maputxe han portat endavant per reivindicar drets del seu poble i l'equitat de gènere. Cridem l’atenció sobre el protagonisme que han tingut dones maputxe en la conjuntura recent: en els processos constitucionals, en els debats sobre el projecte neoliberal, l'extractivisme i el racisme institucional, i en les aliances estratègiques amb els moviments feministes. Les dones maputxe han instal·lat assumptes com l'extractivisme, la despulla i el racisme com a assumptes feministes i també han interpel·lat al moviment feminista a considerar les seves experiències, que són el producte de vivències històriques de despulla i opressió, no només per part de l'Estat ni els homes, sinó també de les dones wingkas o blanc-mestisses. Aquest article posa el focus en les pràctiques i les veus de dones maputxe i, des de les seves veus i experiències, fent-se presents en el moviment feminista i anticolonial tot donant compte de les diversitats existents en el territori ara anomenant Xile.In this article, we propose an analysis from a de-colonial and intersectional perspective of Mapuche women’s historical struggles for the rights of their people and gender equity. We call attention to the contemporary protagonism of Mapuche women in the constitutional processes, in the debates about the neoliberal project, extractivism and institutional racism, and in strategic alliances with feminist movements. Mapuche women have established issues like extractivism, dispossession and racism as feminist issues and have also challenged the feminist movement to consider their experiences, which are the product of historical experiences of dispossession and oppression instigated, not only by the state and men, but also by wingkas or white-mestizo women. This article focuses on the practices and voices of Mapuche women have vehemently established their claims and demands, asserting their presence in the feminist and anti-colonial movements and demonstrating the diversities that exist in the territory now called Chile.Nos hemos propuesto en este artículo, desde una apuesta descolonial y con perspectiva interseccional, analizar las luchas históricas que mujeres mapuche han llevado adelante para reivindicar derechos de su pueblo y la equidad de género. Llamamos atención sobre el protagonismo que han tenido mujeres mapuche en la coyuntura reciente: en los procesos constitucionales, en los debates sobre el proyecto neoliberal, el extractivismo y el racismo institucional, y en las alianzas estratégicas con los movimientos feministas. Las mujeres mapuche han instalado a asuntos como el extractivismo, el despojo y el racismo como asuntos feministas y también han interpelado al movimiento feminista a considerar sus experiencias que son producto de vivencias históricas de despojo y opresión, no solo desde el Estado ni de los varones, sino que también por las mujeres wingkas o blanco-mestizas. Este artículo pone el foco en las prácticas y voces de mujeres mapuche, haciéndose presentes en el movimiento feminista y anticolonial dando cuenta de las desigualdades existentes en el Chile actual

A network-based comparative framework to study conservation and divergence of proteomes in plant phylogenies

Comparative functional genomics offers a powerful approach to study species evolution. To date, the majority of these studies have focused on the transcriptome in mammalian and yeast phylogenies. Here, we present a novel multi-species proteomic dataset and a computational pipeline to systematically compare the protein levels across multiple plant species. Globally we find that protein levels diverge according to phylogenetic distance but is more constrained than the mRNA level. Module-level comparative analysis of groups of proteins shows that proteins that are more highly expressed tend to be more conserved. To interpret the evolutionary patterns of conservation and divergence, we develop a novel network-based integrative analysis pipeline that combines publicly available transcriptomic datasets to define co-expression modules. Our analysis pipeline can be used to relate the changes in protein levels to different species-specific phenotypic traits. We present a case study with the rhizobia-legume symbiosis process that supports the role of autophagy in this symbiotic association

SIRT3 Mediates Multi-Tissue Coupling for Metabolic Fuel Switching

SummarySIRT3 is a member of the Sirtuin family of NAD+-dependent deacylases and plays a critical role in metabolic regulation. Organism-wide SIRT3 loss manifests in metabolic alterations; however, the coordinating role of SIRT3 among metabolically distinct tissues is unknown. Using multi-tissue quantitative proteomics comparing fasted wild-type mice to mice lacking SIRT3, innovative bioinformatic analysis, and biochemical validation, we provide a comprehensive view of mitochondrial acetylation and SIRT3 function. We find SIRT3 regulates the acetyl-proteome in core mitochondrial processes common to brain, heart, kidney, liver, and skeletal muscle, but differentially regulates metabolic pathways in fuel-producing and fuel-utilizing tissues. We propose an additional maintenance function for SIRT3 in liver and kidney where SIRT3 expression is elevated to reduce the acetate load on mitochondrial proteins. We provide evidence that SIRT3 impacts ketone body utilization in the brain and reveal a pivotal role for SIRT3 in the coordination between tissues required for metabolic homeostasis

Playing the Public Lands Game- HONR 3020: Engaging Utah\u27s Public Lands

How to get involved with public land issues and learn what\u27s at stake. Join us as students present a guide that teaches how to locate, navigate, and participate in the various government and public processes for engaging in public lands debates

Competencias para el ejercicio de la dirección de instituciones educativas : reflexiones y experiencias en Iberoamérica

El presente texto es el resultado de las aportaciones al encuentro realizado por los miembros de la Red de Apoyo a la Gestion Educativa (http://www.redage.org) en junio de 2011 en la ciudad de Lima. Constituye el tercer documento de la Serie Informes que ha producido la RedAGE y es expresión del compromiso constitutivo por analizar y difundir temáticas relacionadas con la organizaciÓn y dirección de los sistemas y centros educativos. El ejercicio directivo analizado desde la perspectiva de las competencias es la temática que se aborda en esta ocasión. Por una parte, se continúa la reflexión iniciada con el segundo informe, dedicado a la Dirección de centros educativos en Iberoamérica (http://www.redage.org/files/adjuntos/ Libro%20Red_AGE%20vd.pdf); por otra, se profundiza desde la perspectiva de las competencias con la idea de difundir e impulsar el nuevo enfoque. Tratamos así de un tema incipiente en algunos de los países, pero presente y parte de la agenda de los responsables de la política educativa, con la idea de aportar elementos para las posibles acciones a desarrollar o a mejorar al respecto. Hablamos de competencias y sobre competencias1 y con ello nos referimos a las características de la persona relacionadas con una actuación de éxito en su lugar de trabajo. Se identifican así con la activación y aplicación de manera coordinada de elementos de diferente naturaleza (cognoscitivos, afectivos y procedimentales) para resolver situaciones profesionales concretas. El concepto de competencia es utilizado desde hace tiempo en el campo de la formación profesional, abriéndose camino, poco a poco, en todo el sistema educativo y en los procesos de formación continua, donde la gestión por competencias se ha convertido en un modelo integrador y orientador de las diferentes políticas de recursos humanos